Parkinsonism without dopamine neuron degeneration in aged DOPA-responsive dystonia knockin mice

摘要

BackgroundRecent neuroimaging studies implicate nigrostriatal degeneration as a critical factor in producing late-onset parkinsonism in patients with DRD-causing mutations. However, postmortem anatomical studies do not reveal neurodegeneration in DRD patients. These contrasting findings make it unclear how parkinsonism develops in DRD-mutation carriers.