Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing forces

摘要

We discussmicrotubule-based mechanisms of the mitotic spindle positioning, a key mechanical process that shapes and patterns tissues. The magnitude of the centering forcesindicates that the physical limiton the accuracy and precision of centering isset by the number of contributing microtubules rather than by thermally driven fluctuations.