Ulcerative colitis Crohn’s disease and irritable bowel syndrome have different profiles of extracellular matrix turnover which also reflects disease activity in Crohn’s disease

摘要

BackgroundIncreased protease activity is a key pathological feature of inflammatory bowel disease (IBD). However, the differences in extracellular matrix remodelling (ECM) in Crohn’s disease (CD) and ulcerative colitis (UC) are not well described. An increased understanding of the inflammatory processes may provide optimized disease monitoring and diagnostics. We investigated the tissue remodelling in IBD and IBS patients by using novel blood-based biomarkers reflecting ECM remodelling.