Engineering cell surface function with DNA origami

摘要

We report a specific and reversible method to engineer cell membrane function by embedding DNA origami nanodevices onto the cell surface. We achieve robust membrane functionalization across epithelial, mesenchymal, and non-adherent immune cells with DNA nanoplatforms that enable functions including construction of higher order DNA assemblies at the cell surface and programmed cell-cell adhesion between both homotypic and heterotypic cells via sequence-specific DNA hybridization. We anticipate integration of DNA origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.