Cistrome Cancer: a web resource for integrative gene regulation modeling in cancer

摘要

Cancer results from a breakdown of normal gene expression control, so the study of gene regulation is critical to cancer research. To gain insight into the transcriptional and epigenetic factors regulating abnormal gene expression patterns in cancers, we developed the Cistrome Cancer web resource (). We conducted the systematic integration and modeling of over ten thousand tumor molecular profiles from The Cancer Genome Atlas (TCGA) with over twenty-three thousand ChIP-seq and chromatin accessibility profiles from our Cistrome collection. The results include reconstruction of functional enhancer profiles, “super-enhancer” target genes, as well as predictions of active transcription factors (TF) and their target genes for each TCGA cancer type. Cistrome Cancer reveals novel insights from integrative analyses combining chromatin profiles with tumor molecular profiles, and will be a useful resource to the cancer gene regulation community.