The transcription factors GATA2 and MITF regulateHdc gene expression in mast cells and are required forIgE/mast cell-mediated anaphylaxis

摘要

Background:Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis. Histamine is synthesized by decarboxylating the amino acid histidine, a reaction catalyzed by the Hdc-gene encoded enzyme histidine decarboxylase. However, regulation of the Hdc gene in mast cells is poorly understood.