Acute and Chronic Increases of Circulating Follistatin-like Protein 1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure

摘要

BackgroundFollistatin-like protein 1 (FSTL1) is an emerging cardiokine/myokine that is upregulated in heart failure (HF) and found to be cardioprotective in animal models of cardiac injury. We tested the hypothesis that circulating FSTL1 can affect cardiac function and metabolism under baseline physiological conditions and in HF.