DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative acute and chronic postsurgical pain after spine fusion

摘要

IntroductionThe perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways. Since deoxyribonucleic acid (DNA) methylation is a potent repressor of gene expression, DNA methylation was evaluated at the OPRM1 promoter, as a predictor of preoperative, acute, and chronic postsurgical pain (CPSP).