Updated Follow-Up of a Tolerance Protocol in HLA-identical Renal Transplant Pairs Given Donor Hematopoietic Stem Cells

摘要

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9 ½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 & 8 ½ years post-operatively. There has been continuing elevated T-regulatory (CD4⁺CD25^HighCD127⁻FOXP3⁺) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.