Genome-wide discovery and identification of a novel miRNA signature for recurrence prediction in stage II and III colorectal cancer

摘要

PurposeThe current TNM (Tumor Node Metastasis) staging system is inadequate at identifying high-risk colorectal cancer (CRC) patients. Using a systematic and comprehensive-biomarker discovery and validation approach, we aimed to identify a miRNA-recurrence classifier (MRC) that can improve upon the current TNM-staging as well as superior to currently offered molecular assays.