A Randomized Trial of Brief versus Extended Seizure Prophylaxis after Aneurysmal Subarachnoid Hemorrhage

摘要

BackgroundSeizures occur in 10–20% of patients with subarachnoid hemorrhage (SAH), predominantly in the acute phase. However, anticonvulsant prophylaxis remains controversial, with studies suggesting a brief course may be adequate and longer exposure may be associated with worse outcomes. Nonetheless, in the absence of controlled trials to inform practice, patients continue to receive variable chemoprophylaxis. The objective of this study was to compare brief vs. extended seizure prophylaxis after aneurysmal SAH.