Solid Papillary Breast Carcinomas Resembling the Tall Cell Variant ofPapillary Thyroid Neoplasms (Solid Papillary Carcinomas with Reverse Polarity)Harbor Recurrent Mutations Affecting IDH2 andPIK3CA: A Validation Cohort

摘要

AimsSolid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histologic type of breast cancer that morphologically resembles the tall cell variant of papillary thyroid carcinoma. BPTCs are characterized by IDH2 R172 hotspot somatic mutations or mutually exclusive TET2 somatic mutations, concurrently with mutations affecting PI3K pathway-related genes. We sought to characterize their histology, and investigate the frequency of IDH2 and PIK3CA mutations in an independent cohort of BPTCs, as well as in conventional solid papillary carcinomas (SPCs).