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Tolerance to hypothermic and antinoceptive effects of Δ9-tetrahydrocannabinol (THC) vapor inhalation in rats

机译：耐受Δ9-四氢大麻酚（THC）蒸气吸入对大鼠的低温和抗伤害作用

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摘要

Rationale:A reduced effect of a given dose of Δ⁹-tetrahydrocannabinol (THC) emerges with repeated exposure to the drug. This tolerance can vary depending on THC dose, exposure chronicity and the behavioral or physiological measure of interest. A novel THC inhalation system based on e-cigarette technology has been recently shown to produce the hypothermic and antinociceptive effects of THC in rats.

机译：理由：反复接触该药物会降低给定剂量的Δ^{9 -四氢大麻酚（THC）的作用。该耐受性可根据THC剂量，接触慢性和所关注的行为或生理指标而变化。最近显示了一种基于电子烟技术的新型THC吸入系统，可在大鼠中产生THC的降温和镇痛作用。}

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期刊名称 other
作者
Jacques D. Nguyen; Yanabel Grant; Tony M. Kerr; Arnold Gutierrez; Maury Cole; Michael A. Taffe;
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作者单位

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年(卷),期 -1(172),-1
年度 -1
页码 33–38
总页数 14
原文格式 PDF
正文语种
中图分类
关键词
cannabis marijuana hypothermia nociception tolerance e-cigarette;

机译：大麻;大麻;体温过低;伤害感受;耐受力;电子烟;

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专利

1. Tolerance to hypothermic and antinoceptive effects of Delta 9-tetrahydrocannabinol (THC) vapor inhalation in rats [J] . Nguyen Jacques D., Grant Yanabel, Kerr Tony M., Pharmacology, Biochemistry and Behavior . 2018,第期

机译：δ9-四氢甘油（THC）蒸气吸入大鼠δ9-四氢甘油（THC）蒸汽吸入的耐受性和抗钙化作用的耐受性
2. Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats [J] . Javadi-Paydar Mehrak, Kerr Tony M., Harvey Eric L., Drug and alcohol dependence . 2019,第期

机译：尼古丁和THC蒸气吸入的作用在雄性大鼠中施用电子尼古丁递送系统（末端）给药
3. Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats [J] . Mehrak Javadi-Paydar, Jacques D. Nguyen, Tony M. Kerr, Psychopharmacology . 2018,第9期

机译：δ9-THC和大麻蒸气吸入在雄性大鼠中的影响
4. The Effects of Shear Stress on Endothelial Cells at Hypothermic Temperatures [C] . ASME internatioanl mechanical engineering congress and exposition . 2003

机译：剪切应力对低温温度内皮细胞的影响
5. IMMUNOTOXIC EFFECTS OF INHALATION OF VARIOUS LEVELS OF FORMALDEHYDE VAPOR IN RATS [D] . LEACH, CHESTER LANE. 1983

机译：吸入大鼠甲醛中各种水平的免疫毒理作用
6. Inhaled delivery of Δ9-tetrahydrocannabinol (THC)to rats by e-cigarette vapor technology [O] . Jacques D. Nguyen, Shawn M. Aarde, Sophia A. Vandewater, -1

机译：吸入递送Δ9-四氢大麻酚（THC）电子烟蒸气技术对大鼠
7. Tolerance to hypothermic and antinoceptive effects of ∆9-tetrahydrocannabinol (THC) vapor inhalation in rats [O] . Jacques D. Nguyen, Yanabel Grant, Tony M. Kerr, 2018

机译：对大鼠Δ9-四氢萘酚（THC）蒸气吸入的差异对低温和抗氨基抗性的耐受性

Tolerance to hypothermic and antinoceptive effects of Δ9-tetrahydrocannabinol (THC) vapor inhalation in rats

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