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Estimating epidemiological parameters of a stochastic differential model of HIV dynamics using hierarchical Bayesian statistics

机译:使用分级贝叶斯统计量估计HIV动态随机微分模型的流行病学参数

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摘要

Current estimates of the HIV epidemic indicate a decrease in the incidence of the disease in the undiagnosed subpopulation over the past 10 years. However, a lack of access to care has not been considered when modeling the population. Populations at high risk for contracting HIV are twice as likely to lack access to reliable medical care. In this paper, we consider three contributors to the HIV population dynamics: at-risk population exhaustion, lack of access to care, and usage of anti-retroviral therapy (ART) by diagnosed individuals. An extant problem in the mathematical study of this system is deriving parameter estimates due to a portion of the population being unobserved. We approach this problem by looking at the proportional change in the infected subpopulations. We obtain conservative estimates for the proportional change of the infected subpopulations using hierarchical Bayesian statistics. The estimated proportional change is used to derive epidemic parameter estimates for a system of stochastic differential equations (SDEs). Model fit is quantified to determine the best parametric explanation for the observed dynamics in the infected subpopulations. Parameter estimates derived using these methods produce simulations that closely follow the dynamics observed in the data, as well as values that are generally in agreement with prior understanding of transmission and diagnosis rates. Simulations suggest that the undiagnosed population may be larger than currently estimated without significantly affecting the population dynamics.
机译:对艾滋病流行的最新估计表明,过去10年中,未经诊断的亚人群中该疾病的发病率有所下降。但是,在对人群进行建模时,并未考虑缺乏护理的机会。感染艾滋病毒的高风险人群缺乏可靠医疗服务的可能性是其两倍。在本文中,我们考虑了导致HIV人口动态的三个因素:高风险的人群衰竭,无法获得医疗服务以及被诊断的个人使用抗逆转录病毒疗法(ART)。该系统数学研究中的一个现存问题是由于一部分人口未被观测到而推导参数估计。我们通过查看受感染亚人群的比例变化来解决此问题。我们使用分级贝叶斯统计量来获得感染亚群的比例变化的保守估计。估计的比例变化用于导出随机微分方程(SDE)系统的流行病参数估计。量化模型拟合,以确定感染亚群中观察到的动力学的最佳参数解释。使用这些方法得出的参数估计值会产生与数据中观察到的动态密切相关的模拟,以及通常与先前对传播和诊断率的理解相符的值。模拟表明,未诊断的种群可能比当前估计的种群大,而不会显着影响种群动态。

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  • 期刊名称 other
  • 作者

    Renee Dale; BeiBei Guo;

  • 作者单位
  • 年(卷),期 -1(13),7
  • 年度 -1
  • 页码 e0200126
  • 总页数 15
  • 原文格式 PDF
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