Sterically shielded tetrazoles for fluorogenic photoclick reaction: Tuning cycloaddition rate and product fluorescence

摘要

A panel of sterically shielded tetrazoles with different N-aryl groups were synthesized and subsequently evaluated in the photoinduced tetrazole-alkene cycloaddition reaction. It was found that increase in HOMO energy of the corresponding nitrile imines leads to faster cycloaddition reaction along with red shift in fluorescence emission of the pyrazoline cycloadduct.