A cis-acting Element Downstream of the Mouse Mammary Tumor Virus Major Splice Donor Critical for RNA Elongation and Stability

摘要

Background:The mouse mammary tumor virus (MMTV) encodes a functional signal peptide (SP), a cleavage product of envelope and Rem proteins. SP interacts with a 3’ cis-acting RNA element, the Rem-responsive element (RmRE), to facilitate expression of both unspliced genomic (gRNA) and spliced mRNAs. An additional RmRE, has been proposed at the 5’ end of the genome, facilitating nuclear export of the unspliced gRNA, whereas the 3’ RmRE could facilitate translation of all other mRNAs, including gRNA.