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Correlation between esophageal pH-metry and esophagitis in gastroesophageal reflux disease in children

机译:儿童胃食管反流病中食管pH值测定与食管炎的相关性

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摘要

Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used for diagnosis of the GERD, with the esophagitis degree observed at the upper digestive endoscopy.72 children were included, aged over 4 years old, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with GERD by 24 hours pH-metry (with a positive Boix–Ochoa score), which also underwent the upper digestive endoscopy.Out of the 72 children diagnosed with GERD, 47 (65.28%) had grade A esophagitis and 25 (34.72%) grade B esophagitis. In GERD associated with grade B esophagitis the Boix–Ochoa score is statistically significant higher, compared with the GERD associated with grade A esophagitis (F = 9.76, P = .0036, 95% CI).Upper digestive endoscopy performed in patients with gastroesophageal reflux disease shows the constant presence of esophagitis at all patients. There were only grade A and B esophagitis due to the fact that they are young patients with a relative short history of the disease. The correlation tests show a perfect parallel between the pH-metry scores and the endoscopic lesion. The correlation is so accurate that the pH-metry scores can be sufficient to prove GERD and the grade of esophagitis, the upper digestive endoscopy being reserved only for the cases that does not respond to the medical treatment or have other complications.
机译:胃食管反流(GER)是胃内容物间歇性或永久性进入食道,而胃食管反流疾病(GERD)是引起一系列症状或并发症的反流。该研究将用于诊断GERD的24小时食管pH测量与在上消化内镜下观察到的食道炎程度进行了比较。其中包括72名年龄在4岁以上的儿童在东北小儿胃肠病学区域中心住院罗马尼亚,通过24小时pH值测定法(Boix–Ochoa评分阳性)被诊断为GERD,并且也接受了上消化内镜检查。在被诊断为GERD的72名儿童中,有47名(65.28%)患有A级食管炎,其中25名( 34.72%)B级食管炎。在与B级食管炎有关的GERD中,与与A级食管炎有关的GERD相比,Boix–Ochoa评分具有统计学意义(F = 9.76,P = .0036,95%CI)。在胃食管反流患者中进行上消化内镜检查该疾病表明所有患者均持续存在食道炎。由于A和B级食管炎是年轻的患者,因此该病的病史相对较短。相关性测试显示,pH测量值与内镜病变之间存在完美的平行关系。这种相关性非常精确,以至于pH测度得分足以证明GERD和食管炎的程度,上消化道内窥镜检查仅适用于对药物无反应或有其他并发症的情况。

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