In recent years, with the development of magnified endoscopic technology, the microstructure of the gastric mucosa surface has been widely studied. However, it is unclear why the crypt opening shape of the fundic gland is different from that of the pyloric gland. We attempted to explain the problem by means of physical concepts, mathematical tools and some pathological perspectives. We first constructed an “L” type tubular structure on the basis of the pathology of the gastric mucosa and some geometric principles and then analyzed the distortion of marginal crypt epithelia after we added cells in the model via the mechanism of continuous regeneration. Finally, we determined that the crypt opening shape of the pyloric gland is derived mathematically from that of the fundic gland with the help of the idea of the Riemann sum. According to the derivation of the Euler force, it is possible that the epithelial-mesenchymal transition (EMT) protects the integrity of the gastric mucosa. Our model suggests that the evolution of the fundic gland and the pyloric gland triggers the EMT via elastic deformation. The basic logic of our model is the principle of least action.
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