PDTM-44. INTRACRANIAL EPENDYMOMA: DEVELOPING PRECLINICAL MODELS AND IDENTIFYING NOVEL TREATMENTS

摘要

INTRODUCTIONClinical trials have not identified any effective chemotherapeutic treatments for intracranial ependymomas. This failure is partially explained by the recent identification of 6 molecularly distinct intracranial subgroups. Whilst subgroup specific preclinical investigations and treatments are required, these investigations have been hampered by the rarity of the tumours, failure to identify driver mutations for 5 of the subgroups, and difficulties establishing appropriate models. This study aims to establish patient derived cell lines, brain slice co-culture models and patient derived mouse models of intracranial ependymomas and utilise these models to identify and test novel subgroup specific drug treatments. METHODS/