TRAJECTORIES OF CARDIOVASCULAR RISK FACTORS AND HEALTHY LONGEVITY: THE CARDIOVASCULAR HEALTH STUDY

摘要

The patterns of risk factors that predict healthy longevity - survival to age 90 free of cardiovascular disease (CVD), cognitive impairment, and disability - are uncertain. We assessed cardiovascular risk factors measured repeatedly over late-life in black and white participants in the Cardiovascular Health Study, aged ≥65 at baseline. Among 5,888 participants, 1,889 (32%) survived to 90 by June 16th, 2015. Among those surviving, 57% were free of CVD, 67% were cognitively intact (Modified Mini Mental State Exam>80), and 40% had no history of disability. Models were adjusted for demographic factors. Lower systolic blood pressure before age 80 years was associated with survival to 90; however, the association was attenuated at older age. Kidney function measured at any age was associated with all outcomes. The associations of glucose, dyslipidemia, and obesity varied by outcome. Understanding the risk factor profiles that portend healthy longevity can lead to more targeted interventions.