The Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin Labelling

摘要

Background and Purpose:The aging HIV⁺ population have increased vascular comorbidities, including stroke, and increased cognitive deficits compared to the general population. Arterial spin labelling (ASL) MRI is a technique to measure cerebral blood flow (CBF), and is more sensitive than regional volume loss in the assessing neurodegenerative diseases and cognitive aging. Previous studies have found global cerebral perfusion abnormalities in the HIV⁺ participants. In this study, we evaluated the specific regional pattern of CBF abnormalities in older HIV⁺ participants using quantitative whole-brain ASL.