Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice

摘要

BackgroundNur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains largely elusive. In this study, we used Nur77-deficient (Nur77^−/−) mice and investigated the function of Nur77 in sepsis.