Effects of explant size on epithelial outgrowth thickness stratification ultrastructure and phenotype of cultured limbal epithelial cells

摘要

PurposeTransplantation of limbal stem cells is a promising therapy for limbal stem cell deficiency. Limbal cells can be harvested from either a healthy part of the patient’s eye or the eye of a donor. Small explants are less likely to inflict injury to the donor site. We investigated the effects of limbal explant size on multiple characteristics known to be important for transplant function.