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Increased serum complement C3 and C4 concentrations and their relation to severity of chronic spontaneous urticaria and CRP concentration

机译:血清补体C3和C4浓度升高及其与慢性自发性荨麻疹严重程度和CRP浓度的关系

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摘要

Chronic spontaneous urticaria (CU) is associated with activation of the acute phase response (APR). Nevertheless, APR-associated proteins have not been well characterized as potential biomarkers of the disease severity. To assess the pattern of complement proteins C3 and C4 – the acute phase reactants in patients with CU. C3, C4 and CRP concentrations were measured in serum of 70 patients showing different degrees of urticarial severity as well as in 33 healthy subjects. Serum C3 and C4 concentrations were significantly increased in CU patients as compared with the healthy subjects and exceed the normal lab range by about 5% and 10%, respectively. Significant differences were found between patients with mild and increased CU severity. In addition, significant correlations were observed between C3, C4 and CRP concentrations. More severe CU is characterized by higher production of C3 and C4 complements accompanied by parallel changes in CRP concentration.
机译:慢性自发性荨麻疹(CU)与急性期反应(APR)的激活有关。然而,尚未将APR相关蛋白作为疾病严重程度的潜在生物标记物。评估补体蛋白C3和C4的模式-CU患者的急性期反应物。在70名表现出不同程度的荨麻疹严重程度的患者以及33名健康受试者的血清中测量了C3,C4和CRP浓度。与健康受试者相比,CU患者的血清C3和C4浓度显着增加,分别超出正常实验室范围约5%和10%。在轻度和重度CU严重程度的患者之间发现了显着差异。此外,在C3,C4和CRP浓度之间观察到显着的相关性。更为严重的CU的特征是C3和C4补体的产生更高,并伴随CRP浓度的平行变化。

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