Kinetics and isotype profile of antibody responses in rhesus macaques induced following vaccination with HPV 6 11 16 and 18 L1-virus-like particles formulated with or without Merck aluminum adjuvant

摘要

BackgroundHuman papillomaviruses (HPV) are the most common sexually transmitted viruses. Infection of the cervical epithelium by HPVs can lead to the development of cervical cancer. Recent advances in vaccine research have shown that immunization with papillomavirus-like particles (VLPs) containing the major structural viral protein, L1 from HPV 16 can provide protection from the establishment of a chronic HPV 16 infection and related cervical intraepithelial neoplasia (CIN) in baseline HPV 16 naïve women.