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Utilization of custom electron bolus in head and neck radiotherapy

机译:自定义电子推注在头颈部放射治疗中的利用

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摘要

Conventional methods of treating superficial head and neck tumors, such as the wedge pair technique or the use of multiple electron fields of varying energies, can result in excellent tumor control. However, in some cases, these techniques irradiate healthy tissue unnecessarily and/or create hot and cold spots injunction regions, particularly in patients with complex surface contour modification or varying planning target volume (PTV) thickness. The objective of this work is to demonstrate how bolus electron conformal therapy can be used for these patients. Two patients treated using this technique are presented. The first patient was diagnosed with malignant fibrous histiocytoma involving the right ear concha and was treated with 12‐MeV electrons. The second patient was diagnosed with acinic cell carcinoma of the left parotid gland and was treated with 20‐MeV electrons after having undergone a complete parotidectomy. Each patient's bolus was designed using bolus design tools implemented in an in‐house treatment‐planning system (TPS). The bolus was fabricated using a computer‐controlled milling machine. As part of the quality assurance process to ensure proper fabrication and placement of the bolus, the patients underwent a second computed tomography (CT) scan with the bolus in place. Using that data, the final dose distribution was computed using the Philips Pinnaclehref="#acm20321-bib-0003" rid="acm20321-bib-0003" class=" ref"> 3 TPS (Philips Medical Systems, Andover, MA). Results showed that the 90% isodose surface conformed well to the PTV and that the dose to critical structures such as cord, brain, and lung was well below tolerance limits. Both patients showed no evidence of disease six months post‐radiotherapy. In conclusion, electron bolus conformal therapy is a viable option for treating head and neck tumors, particularly patients having a variable thickness PTV or surface anatomy with surgical defects.PACS number(s): 87.53.Kn
机译:常规的治疗浅表头颈部肿瘤的方法,例如楔形对技术或使用不同能量的多个电子场,可实现出色的肿瘤控制。但是,在某些情况下,这些技术不必要地照射健康组织和/或创建热点和冷点禁区,特别是在表面轮廓修饰复杂或计划目标体积(PTV)厚度不同的患者中。这项工作的目的是证明推注电子适形疗法可用于这些患者。介绍了使用这种技术治疗的两名患者。首例患者被诊断出患有右耳甲的恶性纤维组织细胞瘤,并接受了12-MeV电子治疗。第二例患者被诊断为左腮腺腺癌细胞,并在接受了完整的腮腺切除术后接受了20 MeV电子治疗。使用在室内治疗计划系统(TPS)中实施的推注设计工具设计每个患者的推注。大剂量使用计算机控制的铣床制造。作为确保正确制作和放置弹丸的质量保证过程的一部分,患者在放置弹丸的情况下接受了第二次计算机断层扫描(CT)扫描。使用该数据,使用飞利浦Pinnacle href="#acm20321-bib-0003" rid="acm20321-bib-0003" class=" ref"> 3 < / sup> TPS(飞利浦医疗系统公司,马萨诸塞州安多弗)。结果表明,90%的等剂量表面与PTV吻合良好,并且对关键结构(如脐带,脑和肺)的剂量远低于耐受极限。两名患者在放疗后六个月均未显示疾病迹象。总之,电子推注适形疗法是治疗头颈部肿瘤的可行选择,尤其是具有可变厚度的PTV或具有手术缺陷的表面解剖结构的患者.PACS数:87.53.Kn

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