Effect of ghrelin and its analogues BIM-28131 and BIM-28125 on the expression of myostatin in a rat heart failure model

机译：生长激素释放肽及其类似物BIM-28131和BIM-28125对大鼠心力衰竭模型中肌生长抑制素表达的影响

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BackgroundIn chronic heart failure (CHF), cachexia is a hallmark of the terminal stage of this disease and is associated with a severely reduced quality of life and poor prognosis. Therapeutic options are currently not available. Ghrelin and its analogues BIM-28125 and BIM-28131 (now known as RM-131) have been shown to increase weight in a rat model of CHF. It has been further demonstrated that the expression of myostatin, a negative regulator of skeletal muscle mass, is increased in CHF. The aim of the study was to investigate the influence of ghrelin or its analogues on myostatin in CHF.

机译：背景技术在慢性心力衰竭（CHF）中，恶病质是该疾病终末期的标志，并与生活质量严重降低和预后不良相关。目前尚无治疗选择。 Ghrelin及其类似物BIM-28125和BIM-28131（现称为RM-131）已显示在CHF大鼠模型中增加体重。进一步证明，CHF中肌肉生长抑制素（一种骨骼肌质量的负调节剂）的表达增加。该研究的目的是研究生长素释放肽或其类似物对CHF中肌生长抑制素的影响。

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期刊名称 Journal of Cachexia Sarcopenia and Muscle
作者
Karsten Lenk; Sandra Palus; Robert Schur; Rakesh Datta; Jesse Dong; Michael D. Culler; Stefan Anker; Jochen Springer; Gerhard Schuler; Volker Adams;
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年(卷),期 2013(4),1
年度 2013
页码 63–69
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Myostatin Ghrelin Chronic heart failure Cachexia Muscle wasting TNF-α;

机译：肌生长抑制素;Ghrelin;慢性心力衰竭;恶病质;肌肉消瘦;TNF-α;

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1. Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model [J] . Karsten Lenk, Sandra Palus, Robert Schur, Journal of Cachexia, Sarcopenia and Muscle . 2013,第1期

机译：生长激素释放肽及其类似物BIM-28131和BIM-28125对大鼠心力衰竭模型中肌生长抑制素表达的影响
2. Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model [J] . Karsten Lenk, Sandra Palus, Robert Schur, Journal of Cachexia, Sarcopenia and Muscle . 2013,第1期

机译：生长激素释放肽及其类似物BIM-28131和BIM-28125对大鼠心力衰竭模型中肌生长抑制素表达的影响
3. Effect of ghrelin and its analogues, BIM‐28131 and BIM‐28125, on the expression of myostatin in a rat heart failure model [J] . Anker Stefan, Culler Michael D., Datta Rakesh, Journal of Cachexia, Sarcopenia and Muscle . 2013,第1期

机译：生长激素释放肽及其类似物BIM-28131和BIM-28125对大鼠心力衰竭模型中肌生长抑制素表达的影响
4. Identification of Candidate Drugs for Heart Failure Using Tensor Decomposition-Based Unsupervised Feature Extraction Applied to Integrated Analysis of Gene Expression Between Heart Failure and DrugMatrix Datasets [C] . Y-h. Taguchi International conference on intelligent computing . 2017

机译：基于张量分解的无监督特征提取识别心力衰竭的候选药物，用于心力衰竭和药物基质数据集之间基因表达的综合分析
5. A multi-state model to predict heart failure hospitalizations and all-cause mortality in outpatients with heart failure with reduced ejection fraction: Model derivation and internal validation. [D] . Upshaw, Jenica N. 2015

机译：预测射血分数降低的心力衰竭门诊患者的心力衰竭住院和全因死亡率的多状态模型：模型推导和内部验证。
6. Ghrelin and Its Analogues BIM-28131 and BIM-28125 Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model [O] . Sandra Palus, Robert Schur, Yoshihiro J. Akashi, 2011

机译：Ghrelin及其类似物BIM-28131和BIM-28125在大鼠心力衰竭模型中改善体重并调节MuRF-1和MAFbx的表达
7. Ghrelin and Its Analogues, BIM-28131 and BIM-28125, Improve Body Weight and Regulate the Expression of MuRF-1 and MAFbx in a Rat Heart Failure Model [O] . Palus, Sandra, Schur, Robert, Akashi, Yoshihiro J., 2011

机译：Ghrelin及其类似物BIM-28131和BIM-28125在大鼠心力衰竭模型中改善体重并调节MuRF-1和MAFbx的表达

Effect of ghrelin and its analogues BIM-28131 and BIM-28125 on the expression of myostatin in a rat heart failure model

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