Does early initiation of ART in infants affect virological and resistance outcomes? Data from the CHER trial after 6 years of follow-up

摘要

Purpose of the studyVirological outcomes and resistance patterns in children initiating protease inhibitor (PI)-based antiretroviral therapy (ART) immediately following HIV-1 diagnosis are not well described. Challenges include maintaining adherence in asymptomatic patients with very high pre-ART viral loads. The CHER trial compared deferred but continuous ART (arm 1) with early limited ART (arms 2 and 3).