Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety

摘要

Background and the purpose of the studyPiperazinyl quinolones such as ciprofloxacin, ofloxacin and levofloxacin are an important group of quinolone antimicrobials which are widely used in the treatment of various infectious diseases. In the present study, we synthesized a new series of levofloxacin derivatives and evaluated their antibacterial activities.