One-step synthesis of Lycopodium alkaloid (-)-huperzine W via Suzuki-Miyaura coupling

摘要

The first total synthesis of (−)-huperzine W (>1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide >2 and 2-allylpyrrolidinone >4. Evaluation of the AchE inhibition of synthetic huperzine W was also carried out. Electronic Supplementary MaterialSupplementary material is available for this article at 10.1007/s13659-012-0084-2 and is accessible for authorized users.