Temporal regularity of intrinsic cerebral activity in patients with chronic primary insomnia: a brain entropy study using resting‐state fMRI

摘要

IntroductionSeveral neuroimaging studies have suggested that patients with chronic primary insomnia (CPI) exhibit anatomical and functional alterations of the brain, but the temporal regularity in spontaneous neuronal activity remains unknown. Here, brain entropy (BEN), a data‐driven method used to measure the signal regularity of a time series, was applied for the first time to investigate changes in the entire brain at the voxel level.