Evaluation of two intraoperative gamma detectors for assessment of 177Lu activity concentration in vivo

摘要

BackgroundPatients with somatostatin receptor-expressing neuroendocrine tumours can be treated with intravenously administered ¹⁷⁷Lu-octreotate. Few patients are cured with the present protocol due to the current dose limitation of normal organs at risk, such as the kidneys. By locally administering ¹⁷⁷Lu-octreotate to the liver for the purpose of treating liver metastases, a substantially reduced absorbed dose to organs at risk could be achieved. The development of such a technique requires the capability of measuring the ¹⁷⁷Lu activity concentration in tissues in vivo. The aim of this study was to evaluate different performance parameters of two commercially available intraoperative gamma detectors in order to investigate whether intraoperative gamma detector measurements could be used to determine ¹⁷⁷Lu activity concentration in vivo.