Effects of anti‐β2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity

机译：抗β2GPI抗体对人脐静脉内皮细胞VWF释放和ADAMTS13活性的影响

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摘要

Essentials class="unordered" style="list-style-type:disc" id="rth212090-list-0001">The antiphospholipid syndrome predisposes to thrombosis due to activation of endothelium and blood components.The role of anti‐β2GPI antibodies in VWF release and ADAMTS13 function is not well understood.Some anti‐β2GPI antibodies induce endothelial release of soluble VWF but not VWF strings.An anti‐β2GPI antibody can decrease ADAMTS13 activity in vitro similar to ex vivo results.

机译：要点 class =“ unordered” style =“ list-style-type：disc” id =“ rth212090-list-0001”> <！-list-behavior = unordered prefix-word = mark-type = disc max-label -size = 0-> 由于内皮和血液成分的激活，抗磷脂综合征易形成血栓形成。抗β2GPI抗体在VWF释放和ADAMTS13功能中的作用尚不清楚。一些抗β2GPI抗体诱导内皮释放可溶性VWF，但不诱导VWF弦。抗β2GPI抗体可以降低体外ADAMTS13活性，类似于离体结果。

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期刊名称 Research and Practice in Thrombosis and Haemostasis
作者
Christopher J. Ng; Keith R. McCrae; Katrina Ashworth; Lucas J. Sosa; Venkaiah Betapudi; Marilyn J. Manco‐Johnson; Alice Liu; Jing‐Fei Dong; Dominic Chung; Tara C. White‐Adams; José A. López; Jorge Di Paola;
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作者单位

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年(卷),期 2018(2),2
年度 2018
页码 380–389
总页数 10
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
ADAMTS13 antiphospholipid syndrome endothelial cells von Willebrand factor;

机译：ADAMTS13;抗磷脂综合征;内皮细胞;血管性血友病因子;

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专利

1. Effects of anti‐β2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity [J] . Christopher J. Ng, Keith R. McCrae, Katrina Ashworth, Research and practice in thrombosis and haemostasis. . 2018,第2期

机译：抗β2GPI抗体对人脐静脉内皮细胞VWF释放和ADAMTS13活性的影响
2. PLATELETS ACTIVATED BY THE anti-β2GPI/β2GPI COMPLEX RELEASE MICRORNAS TO INHIBIT MIGRATION AND TUBE FORMATION OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS [J] . Yanfen Zhang, Wenjing Zhang, Caijun Zha, Cellular & molecular biology letters. . 2018,第1期

机译：抗β2GPI/β2GPI复合释放微RNA活化的血小板可抑制人脐静脉内皮细胞的迁移和管形成
3. In Vitro Effects of Antiphospholipid Syndrome-IgG Fractions and Human Monoclonal Antiphospholipid IgG Antibody on Human Umbilical Vein Endothelial Cells and Monocytes: Promotion of Procoagulant Activity and Inflammation [J] . Natascha Clemens, Katrin Frauenknecht, Aviva Katzav, Annals of the New York Academy of Sciences . 2009,第期

机译：抗磷脂综合症IgG组分和人单克隆抗磷脂IgG抗体对人脐静脉内皮细胞和单核细胞的体外作用：促进促凝血活性和炎症。
4. Inhibitory effects of tea catechins on invasion of human fibrosarcoma HT1080 cells to the monolayer of human umbilical vein endothelial cells [C] . Maeda-Yamamoto Mari, Osada Kazuhiro, Yamaguchi Yuichi, Annual Meeting of the Japanese Association for Animal Cell Technology . 1998

机译：茶儿茶素对人纤维瘤HT1080细胞侵袭人脐静脉内皮细胞单层侵袭的抑制作用
5. Effects of cyclic strain on the gene expression of human umbilical vein endothelial cells as determined through microarray technology. [D] . Frye, Stacie Renee. 2003

机译：通过芯片技术确定循环应变对人脐静脉内皮细胞基因表达的影响。
6. Platelets activated by the anti-β2GPI/β2GPI complex release microRNAs to inhibit migration and tube formation of human umbilical vein endothelial cells [O] . Yanfen Zhang, Wenjing Zhang, Caijun Zha, 2018

机译：抗β2GPI/β2GPI复合物激活的血小板释放microRNA抑制人脐静脉内皮细胞的迁移和管形成
7. Effects of anti-β2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity [O] . Christopher J. Ng, Keith R. McCrae, Katrina Ashworth, 2018

机译：抗β2GPI抗体对人脐静脉内皮细胞和Adamts13活性VWF释放的影响

Effects of anti‐β2GPI antibodies on VWF release from human umbilical vein endothelial cells and ADAMTS13 activity

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