Distribution and role of high‐risk human papillomavirus genotypes in women with cervical intraepithelial neoplasia: A retrospective analysis from Wenzhou southeast China

摘要

To add the growing literature on baseline of high‐risk human papillomavirus (HR‐HPV) genotype distribution in cervical intraepithelial neoplasia (CIN) before the widespread using of HPV vaccines in Chinese mainland and to improve risk stratification of HR‐HPV–positive women. Retrospectively, the data of age, cervical HPV genotypes, cytology, and pathology were collected from 1166 patients who received loop electrosurgical excision procedure (LEEP). HPV genotypes were analyzed with Flowcytometry Fluorescence Hybridization Method. And then HPV prevalence, HR‐HPV genotype distribution and the correlation of HR‐HPV genotypes with CIN2+ (CIN2 or severer) were analyzed. The role of multiple style="fixed-case">HR‐ style="fixed-case">HPV types infection with or without style="fixed-case">HPV16/18 in the pathogenesis of style="fixed-case">CIN2+ was also analyzed. The 6 most common style="fixed-case">HR‐ style="fixed-case">HPV genotypes were style="fixed-case">HPV16, 58, 52, 33, 18, and 31 in descending order. Compared to style="fixed-case">HR‐ style="fixed-case">HPV–negative women, style="fixed-case">HPV16, 33 or 58 positive women had higher risk of style="fixed-case">CIN2+ ( style="fixed-case">OR = 5.10, 95% style="fixed-case">CI = 2.68‐9.70; style="fixed-case">OR = 3.09, 95% style="fixed-case">CI = 1.39‐6.84; style="fixed-case">OR = 3.57, 95% style="fixed-case">CI = 1.85‐6.89, respectively). And women who were infected by multiple style="fixed-case">HR‐ style="fixed-case">HPV types infection with style="fixed-case">HPV16/18 also had higher risk of style="fixed-case">CIN2+ ( style="fixed-case">OR = 2.58, 95% style="fixed-case">CI = 1.35‐4.92). However, multiple style="fixed-case">HR‐ style="fixed-case">HPV types infection without style="fixed-case">HPV16/18 did not increase the risk significantly (P = .08). Compare to bivalent Cervarix^® and quadrivalent Gardasil^®, style="fixed-case">HPV prophylactic vaccine targeting style="fixed-case">HPV31, 33, 52, and 58 might provide women more protection from style="fixed-case">HPV‐induced cervical cancer in China. The women who infected by style="fixed-case">HPV16, 33, 58, or multiple style="fixed-case">HR‐ style="fixed-case">HPV types with style="fixed-case">HPV16/18 have higher risk of style="fixed-case">CIN2+ and need to be paid more attention in screening processes. And the role of multiple style="fixed-case">HR‐ style="fixed-case">HPV types infection without style="fixed-case">HPV16/18 needs be further identified in more studies.