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Effects of a Fixed-Dose Co-Formulation of Daclatasvir Asunaprevir and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects

机译：达卡他韦阿舒那普韦和贝克拉布韦固定剂量共制剂对健康受试者中细胞色素P450鸡尾酒和药物转运蛋白底物药代动力学的影响

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BackgroundA fixed-dose combination of daclatasvir (DCV; hepatitis C virus NS5A inhibitor), asunaprevir (ASV; non-structural protein 3 inhibitor), and beclabuvir (BCV; non-structural protein 5B inhibitor) is approved in Japan for hepatitis C virus genotype 1.

机译：背景技术日本批准了达卡他韦（DCV;丙型肝炎病毒NS5A抑制剂），asunaprevir（ASV;非结构性蛋白3抑制剂）和贝克拉布韦（BCV;非结构性蛋白5B抑制剂）的固定剂量组合在日本被批准用于丙型肝炎病毒基因型1。

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期刊名称 Drugs in RD
作者
Tushar Garimella; Xiaolu Tao; Karen Sims; Yi-Ting Chang; Jignasa Rana; Elsa Myers; Megan Wind-Rotolo; Rahul Bhatnagar; Timothy Eley; Frank LaCreta; Malaz AbuTarif;
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年(卷),期 2018(18),1
年度 2018
页码 55–65
总页数 11
原文格式 PDF
正文语种
中图分类药学 ;
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1. Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects [J] . Tushar Garimella, Xiaolu Tao, Karen Sims, Drugs in R&D . 2018 ,第1期

机译：固定剂量共同配制的Daclatasvir，Asunaprevir和Beclabuvir对健康受试者中细胞色素P450鸡尾酒和药物转运蛋白底物的药代动力学的影响
2. PHARMACOKINETICS OF CYTOCHROME P450 PROBE SUBSTRATES IN HEALTHY SUBJECTS AND PSORIASIS PATIENTS: A MODEL-BASED COMPARISON TO INFORM THERAPEUTIC PROTEINS-DRUGS INTERACTION POTENTIAL. [J] . Mohamed M., Sathe A., Othman A. Clinical Pharmacology and Therapeutics . 2020 ,第S1期

机译：健康受试者和牛皮癣患者中细胞色素P450探针底物的药代动力学：基于模型的比较，以通知治疗蛋白 - 药物的相互作用电位。
3. Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects [J] . Yamazaki Takao, Desai Amit, Goldwater Ronald, Clinical pharmacology in drug development . 2017 ,第Suppla1期

机译：异戊酰唑与细胞色素P450酶底物中的药代动力学效应中产，休闲术，咖啡因，右三甲甲烷及其健康受试者的美沙酮
4. Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes [C] . Miao Hao, Yuqing Zhao, Peizhan Chen, 第四届国际分子模拟与信息技术应用学术会议（The 4th International Conference of Molecular Simulations and Applied Informatics Technologies）论文集 . 2008

机译：人参皂甙对药物代谢性P450酶活性的影响与结构活性关系和底物依赖现象
5. A study to investigate the mechanisms of Danshen-drug interactions using cytochrome P450 probe substrates. [D] . Wang, Xin. 2007

机译：利用细胞色素P450探针底物研究丹参药物相互作用的机制的研究。
6. Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion Repaglinide Caffeine Dextromethorphan and Methadone in Healthy Subjects [O] . Takao Yamazaki, Amit Desai, Ronald Goldwater, -1

机译：异沙康康唑与细胞色素P450酶底物安非他酮瑞格列奈咖啡因右美沙芬和美沙酮的共同药动学作用
7. Fixed-Dose Combination Therapy With Daclatasvir, Asunaprevir, and Beclabuvir for Noncirrhotic Patients With HCV Genotype 1 Infection [O] . Poordad, Fred, Sievert, William, Mollison, Lindsay, 2015

机译：HCV基因型1感染非肝硬化患者的达卡他韦，阿舒那韦和贝克拉布韦固定剂量联合疗法

Effects of a Fixed-Dose Co-Formulation of Daclatasvir Asunaprevir and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects

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