Impact of Vancomycin Serum Trough Concentrations and Vancomycin AUC/MIC on Vancomycin Response In-Hospital Outcomes and Acute Kidney Injury in Pediatric Staphylococcus aureus Pneumonia

摘要

BackgroundVancomycin AUC/MIC > 400 was initially shown to be beneficial in adults with staphylococcal pneumonia. Current practice guidelines recommend targeting serum vancomycin trough concentrations (VTC) of 15–20 µg/ml in adults with severe MRSA infection to approximate these AUC/MIC goals. Small studies have shown no benefit to VTC > 15 µg/ml in children with osteomyelitis or bacteremia. We describe the impact of VTC and AUC/MIC on outcomes of pediatric S. aureuspneumonia.