Pharmacokinetic Assessment of Continuous Infusion Ceftolozane/Tazobactam for Drug-Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection

摘要

Background Pseudomonas aeruginosa is a common pathogen in left ventricular assist device (LVAD) infections. Ceftolozane/tazobactam (C/T) is a β-lactam/β-lactamase inhibitor with activity against P. Aeruginosa, including multi-drug-resistant (MDR) isolates. We describe the novel use of continuous infusion (CI) C/T with therapeutic drug monitoring in a 70-year-old man who developed a MDR P. Aeruginosa LVAD driveline infection.