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In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075 Bromfenac Ophthalmic Solution 0.07 and Nepafenac/Amfenac Ophthalmic Suspension 0.3 in Rabbits

机译：溴芬酸滴眼液0.075％溴芬酸滴眼液0.07％和Nepafenac / Amfenac滴眼液在兔体内的体内药代动力学为0.3％

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IntroductionLittle is known of the ocular distribution characteristics of currently branded non-steroidal anti-inflammatory drugs (NSAIDs) in the United States. This study was designed to predict the ocular bioavailability characteristics in humans using Dutch Belted rabbits as a surrogate. Commercially available, topically-applied NSAIDs containing bromfenac or nepafenac/amfenac were evaluated.

机译：简介对美国目前使用的非甾体类抗炎药（NSAID）的眼部分布特征知之甚少。这项研究旨在使用荷兰腰带兔作为替代品来预测人眼的生物利用度特征。评价了含有溴芬酸或尼泊芬酸/安非那定的可商购的，局部应用的NSAID。

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期刊名称 Ophthalmology and Therapy
作者
John D. Sheppard; Paul C. Cockrum; Angela Justice; Mark C. Jasek;
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作者单位

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年(卷),期 2018(7),1
年度 2018
页码 157–165
总页数 9
原文格式 PDF
正文语种
中图分类眼科学;
关键词
Aqueous humor Choroid Iris-ciliary body NSAID Ocular Pharmacokinetics PK Retina Sclera;

机译：房水;脉络膜;虹膜睫状体;NSAID;眼;药代动力学;PK;视网膜;巩膜;

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专利

1. In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits [J] . John D. Sheppard, Paul C. Cockrum, Angela Justice, Ophthalmology and therapy. . 2018,第1期

机译：溴芬酸滴眼液0.075％，溴芬酸滴眼液0.07％和Nepafenac / Amfenac滴眼液在兔体内的体内药代动力学为0.3％
2. In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits [J] . Cockrum Paul, Justice Angela, Jasek Mark C., Investigative ophthalmology & visual science . 2018,第9期

机译：在溴芬酵母眼科溶液的体内药代动力学0.075％，Bromfenac眼科溶液0.07％，Nepafenac / amfenac眼科悬浮液0.3％在兔子
3. In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075%, Bromfenac Ophthalmic Solution 0.07%, and Nepafenac/Amfenac Ophthalmic Suspension 0.3% in Rabbits [J] . Cockrum Paul, Justice Angela, Jasek Mark C., Investigative ophthalmology & visual science . 2018,第9期

机译：在溴芬酵母眼科溶液的体内药代动力学0.075％，Bromfenac眼科溶液0.07％，Nepafenac / amfenac眼科悬浮液0.3％在兔子
4. Trans-Scleral Ophthalmic Drug Delivery from Silicone-Based Devices:I. Long-term In-Vivo Studies in NZW Rabbits [C] . Yoseph Yaacobi, James Chastain, Lisa Lowseth, Annual meeting of the Society For Biomaterials . 2003

机译：基于硅酮的装置的跨巩膜眼科药物递送：I. NZW家兔的长期体内研究
5. Spectral domain optical coherence tomography system development for in vivo ophthalmic imaging [D] . Zhao, Mingtao. 2009

机译：用于体内眼科成像的光谱域光学相干断层扫描系统开发
6. Correction to: In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075 Bromfenac Ophthalmic Solution 0.07 and Nepafenac/Amfenac Ophthalmic Suspension 0.3 in Rabbits [O] . John D. Sheppard, Paul C. Cockrum, Angela Justice, 2019

机译：校正至：兔子中的溴芬酸眼药水0.075％溴芬酸眼药水0.07％和Nepafenac / Amfenac眼药水在兔体内的体内药代动力学为0.3％
7. Bromfenac Ophthalmic Solution 0.07 Versus Nepafenac Ophthalmic Suspension 0.3 for Post-Cataract Surgery Inflammation: A Pilot Study of Identical Dosing Regimens with Pre-Surgical “Pulse” Dose [O] . Steven M. Silverstein 2019

机译：Bromfenac眼科溶液0.07％与Nepafenac眼科悬浮液0.3％对白内障手术炎症：相同给药方案具有前手术前的“脉冲”剂量的试验研究

In Vivo Pharmacokinetics of Bromfenac Ophthalmic Solution 0.075 Bromfenac Ophthalmic Solution 0.07 and Nepafenac/Amfenac Ophthalmic Suspension 0.3 in Rabbits

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