O10.5. ABNORMAL MODULAR ORGANIZATION OF THE FUNCTIONAL CONNECTOME PREDICTS CONVERSION TO PSYCHOSIS IN CLINICAL HIGH-RISK YOUTH

摘要

BackgroundThe first episode of schizophrenia is typically preceded by a prodromal phase characterized by sub-threshold symptoms and declining functioning. Elucidating the neurobiological substrate of prodromal symptoms that progress into overt psychotic illness is crucial to the development of early detection and intervention strategies for schizophrenia. In this study, we performed a functional connectome analysis in a large group of adolescents and young adults at Clinical High Risk (CHR) for schizophrenia. We aim to assess whether, and if so how, baseline connectome organization distinguishes CHR youth that go on to develop psychosis.