S156. FRONTO-STRIATAL FUNCTIONAL CONNECTIVITY AND STRIATAL DOPAMINE CAPACITY IN TREATMENT-RESPONSIVE AND REFRACTORY SCHIZOPHRENIA

摘要

BackgroundSchizophrenia is thought to be a heterogeneous disorder and evidences reflect categorically distinct subtypes according to the antipsychotic treatment response. Altered frontostriatal functional connectivity (FC) in schizophrenia and its correlation with antipsychotic treatment response also suggests divergence of underlying pathophysiologic mechanism. Meanwhile, the observations that prefrontal activity correlates with striatal dopaminergic function, leads to the hypothesis that the disrupted frontostriatal FC would be related with altered dopaminergic pathway in schizophrenia. The aim of this study was to investigate the relationship between frontostriatal FC and striatal dopaminergic activity in patients with schizophrenia according to the responsiveness to first-line antipsychotic drug.