S221. QUANTITATIVE SYSTEMS PHARMACOLOGY AS AN ALTERNATIVE TO CHLORPROMAZINE EQUIVALENTS: PREDICTIVE VALIDATION FROM A CRIS DATABASE EXPERIMENT

摘要

BackgroundPolypharmacy is common in real clinical practice and in pharma-sponsored clinical trials. Chlorpromazine equivalents do not take into account pharmacodynamic interactions of drug combinations. If there is a sufficiently deep calibration set available, bio-informatics approaches can build classifiers for clinical phenotypes. However, this is not always the case which severely limits the generalizability of the predictions.