S143. NEURAL CORRELATES OF INTENTION AND BELIEF INFERENCE RELATIVE TO EMOTION ATTRIBUTION TO OTHERS IN SCHIZOPHRENIA AND PSYCHOSIS PRONENESS: ACTIVATION LIKELIHOOD ESTIMATION META-ANALYSIS

摘要

BackgroundSocial cognition can be briefly defined as the ability to interact with and understand others. It involves several cognitive processes that are considered as critical for an adapted social functioning. In patients with schizophrenia (SCZ) and subjects prone to psychosis (PP), a number of studies have revealed impairments in the abilities to infer beliefs, intentions or emotions of others. Cognitive tasks specifically addressing these abilities have also revealed abnormal neural processing in these subjects. However, these studies have not yet been compared in order to identify shared or distinct functional brain networks underlying these processes in the two subject groups.Therefore, we aimed to determine whether the neurofunctional correlates of intention/belief attribution are distinct from those of emotional inference in SCZ and PP compared to healthy controls (HC). We further attempted to identify neuroimaging markers of psychosis endophenotype in mentalizing tasks. Finally, we examined shared and distinct brain regions involved in intention/belief attribution relative to emotional inference in SCZ.