Association of NKX2‐5 GATA4 and TBX5 polymorphisms with congenital heart disease in Egyptian children

摘要

BackgroundSeveral genes encoding transcription factors are known to be the primary cause of congenital heart disease. NKX2‐5 and GATA4 were the first congenital heart disease–causing genes identified by linkage analysis. This study designed to study the association of five single–nucleotide variants of NKX2‐5, GATA4, and TBX5 genes with sporadic nonsyndromic cases of a congenital cardiac septal defect in Egyptian children.