Effects of RHD gene polymorphisms on distinguishing weak D or DEL from RhD− in blood donation in a Chinese population

摘要

BackgroundWeak D or DEL red blood cell units may be mistyped as RhD− by current serology assays, which can lead to incompatible transfusion to RhD− recipients and further cause anti‐D immunization. Molecular RHD blood group typing is a very effective method for overcoming current technical limits. The purpose of this study was to identify RHD single‐nucleotide polymorphisms (SNPs) and compare the genotype prevalence among confirmed RhD− individuals in a Chinese population as well as explore effective biomarkers for current weak D or DEL detection before blood transfusion.