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Consequences of a high incidence of microsatellite instability and BRAF‐mutated tumors: A population‐based cohort of metastatic colorectal cancer patients

机译：微卫星不稳定性和BRAF突变的肿瘤高发的后果：基于人群的转移性结直肠癌患者队列

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BackgroundImmunotherapy for patients with microsatellite‐instable (MSI‐H) tumors or BRAF‐inhibitors combination treatment for BRAF‐mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the frequency of these molecular changes in trial patients are low. Unselected population‐based studies of these molecular changes are warranted.

机译：背景技术对微卫星不稳定（MSI-H）肿瘤的患者进行免疫疗法或对转移性结直肠癌（mCRC）的BRAF突变（mutBRAF）肿瘤进行BRAF抑制剂联合治疗是有希望的，但是试验患者中这些分子改变的频率很低。对这些分子变化进行未经选择的基于人群的研究是必要的。

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期刊名称 Cancer Medicine
作者
Kristine Ø. Aasebø; Anca Dragomir; Magnus Sundström; Artur Mezheyeuski; Per‐Henrik Edqvist; Geir Egil Eide; Fredrik Ponten; Per Pfeiffer; Bengt Glimelius; Halfdan Sorbye;
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年(卷),期 2019(8),7
年度 2019
页码 3623–3635
总页数 13
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
colorectal neoplasm microsatellite instability proto‐oncogene proteins B‐raf prognosis neoplasm metastasis KRAS protein;

机译：大肠肿瘤;微卫星不稳定性;原癌基因蛋白;B-raf;预后;肿瘤转移;KRAS蛋白;

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专利

1. Consequences of a high incidence of microsatellite instability and BRAF‐ mutated tumors: A population‐based cohort of metastatic colorectal cancer patients [J] . Kristine ?. Aaseb?, Anca Dragomir, Magnus Sundstr?m, Cancer Medicine . 2019,第7期

机译：微卫星不稳定性和BRAF-突变肿瘤发病率的后果：一种基于人群的转移性结直肠癌患者
2. Dabrafenib and trametinib activity in a patient with BRAF V600E mutated and microsatellite instability high (MSI-H) metastatic endometrial cancer [J] . Michele Moschetta, Gabriel Mak, Joana Hauser, Experimental Hematology Oncology . 2017,第1期

机译：患有BRAF V600E突变和微卫星不稳定性高（MSI-H）转移性子宫内膜癌的患者的达布拉非尼和曲美替尼活性
3. Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients [J] . J B Rawson, M Mrkonjic, D Daftary, British Journal of Cancer . 2011,第12期

机译：WNT5a的启动子甲基化与两种大群结肠直肠癌患者的微卫星不稳定性和BRAF V600E突变有关
4. Isolation of Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer Using Label-Free Microfluidic Technology for Enumeration and Detection of KRAS, BRAF, PIK3CA Mutation [C] . Haiyan Emily Liu, Evelyn Kidess-Sigal, Melanie Triboulet, International Molecular Medicine Tri-Conference. . 2016

机译：使用无标记微流体技术分离转移性结肠直肠癌患者的循环肿瘤细胞进行募准和检测KRA，BRAF，PIK3CA突变
5. A link between TGFbeta and intraepithelial tumor infiltrating lymphocytes in microsatellite instability-high colorectal cancer. [D] . Baker, Kristi Dorothy. 2008

机译：TGFbeta和微卫星不稳定性高结直肠癌中上皮内肿瘤浸润淋巴细胞之间的联系。
6. Impact of BRAF MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study [O] . Hassan Brim, Pooneh Mokarram, Fakhraddin Naghibalhossaini, 2008

机译：基于BRAFMLH1对人群微卫星不稳定性高结直肠癌发生率的影响
7. High BRAF Mutation Frequency and Marked Survival Differences in Subgroups According to KRAS/BRAF Mutation Status and Tumor Tissue Availability in a Prospective Population-Based Metastatic Colorectal Cancer Cohort [O] . Sorbye, Halfdan, Dragomir, Anca, Sundström, Magnus, 2015

机译：根据预期的基于人群的转移性结直肠癌队列中的KRAS / BRAF突变状态和肿瘤组织可用性，高BRAF突变频率和亚组的明显生存差异

Consequences of a high incidence of microsatellite instability and BRAF‐mutated tumors: A population‐based cohort of metastatic colorectal cancer patients

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