Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

摘要

Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D (>1–>4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of >1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of >2, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover, >1 and >4 were found to exhibited anticoagulant activity, while >3 and >4 were found to possess anti-platelet aggregation activity.Electronic supplementary materialThe online version of this article (10.1007/s13659-019-0203-4) contains supplementary material, which is available to authorized users.