Radiation dosimetry of 18F-PSS232—a PET radioligand for imaging mGlu5 receptors in humans

摘要

Purpose(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[¹⁸F]-fluoroethoxy)propyl) oxime ([¹⁸F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising results in rodents and humans. The aim of this study was to estimate the radiation dosimetry and biodistribution in humans, to assess dose-limiting organs, and to demonstrate safety and tolerability of [¹⁸F]-PSS232 in healthy volunteers.