Radionuclide generator-based production of therapeutic 177Lu from its long-lived isomer 177mLu

机译：从放射性核素发生器中长寿命异构体177mLu生产治疗性177Lu

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摘要

BackgroundIn this work, a lutetium-177 (¹⁷⁷Lu) production method based on the separation of nuclear isomers, ^177mLu & ¹⁷⁷Lu, is reported. The ^177mLu-¹⁷⁷Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction.

机译：背景在这项工作中，基于分离核异构体^{177m Lu和^{177 Lu的a 177（^{177 Lu）生产方法是报告。 ^{177m Lu- ^{177 Lu的分离是通过使用DOTA和DOTA标记的肽（DOTATATE）并进行液-液萃取来进行的。}}}}}

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期刊名称 EJNMMI Radiopharmacy and Chemistry
作者
Rupali Bhardwaj; Hubert Th. Wolterbeek; Antonia G. Denkova; Pablo Serra-Crespo;
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作者单位

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年(卷),期 2019(4),-1
年度 2019
页码 13
总页数 12
原文格式 PDF
正文语种
中图分类药学;
关键词
Lutetium-177 sup177m/supLu/sup177/supLu radionuclide generator Nuclear isomer separation sup177/supLu production;

机译：ute 177;sup 177m / sup Lu / sup 177 / sup Lu放射性核素发生器;核异构体分离;sup 177 / sup Lu产生;

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专利

1. Radionuclide generator-based production of therapeutic 177 Lu from its long-lived isomer 177m Lu [J] . Rupali Bhardwaj, Hubert Th. Wolterbeek, Antonia G. Denkova, EJNMMI Radiopharmacy and Chemistry . 2019,第1期

机译：从放射性核素发生器中长寿命异构体177m Lu产生治疗性177 Lu
2. Consequences of meta-stable 177mLu admixture in 177Lu for patient dosimetry [J] . DepartmentofNuclearMedicineErasmusMC Current radiopharmaceuticals . 2015,第2期

机译：177Lu中亚稳态177mLu外加剂对患者剂量的影响
3. Quantitative SPECT/CT reconstruction for 177Lu and 177Lu/ 90Y targeted radionuclide therapies [J] . ShcherbininS., Piwowarska-BilskaH., CellerA., Physics in medicine and biology. . 2012,第18期

机译：177Lu和177Lu / 90Y靶向放射性核素疗法的定量SPECT / CT重建
4. Multi beam emitters as joint optical laser complex and ion-optical system for laser selection of atoms, molecules, isotopes, isomers, long-lived and short-lived radionuclides in different spheres from γ-laser and atomic energetics to the medicine and gen [C] . S.V.Karyagin Conference on ultrafast optics and superstrong laser fields . 2001

机译：多光束发射器作为联合光学激光复合物和用于激光选择原子，分子，同位素，异构体，长寿命和短寿命放射性核素的离子光学系统，从γ-激光和原子能对药物和原子的不同领域
5. Production and Applications of Long-Lived Positron-Emitting Radionuclides. [D] . Graves, Stephen A. 2017

机译：长寿命正电子发射放射性核素的生产和应用。
6. Production and characterization of no-carrier-added 161Tb as an alternative to the clinically-applied 177Lu for radionuclide therapy [O] . Nadezda Gracheva, Cristina Müller, Zeynep Talip, 2019

机译：无载体添加的161Tb的生产和表征可替代临床应用的放射性核素177Lu
7. Solid phase extraction-based separation of the nuclear isomers 177mLu and 177Lu [O] . Rupali Bhardwaj, Hubert T. Wolterbeek, Antonia G. Denkova, 2020

机译：基于固相萃取的核异构体分离177mlu和177室
8. Calculations of long-lived isomer production in neutron reactions [R] . Chadwick, M. B., Young, P. G. 1991

机译：计算中子反应中长寿命异构体的产生

Radionuclide generator-based production of therapeutic 177Lu from its long-lived isomer 177mLu

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