Blood group variants are characteristic of population groups, and can show conspicuous geographic patterns. Interest in the global prevalence of the Duffy blood group variants is multidisciplinary, but of particular importance to malariologists due to the resistance generally conferred by the Duffy-negative phenotype against Plasmodium vivax infection. Here we collate an extensive geo-database of surveys, forming the evidence-base for a multi-locus Bayesian geostatistical model to generate global frequency maps of the common Duffy alleles to refine the global cartography of the common Duffy variants. We show that the most prevalent allele globally was FY*A, while across sub-Saharan Africa the predominant allele was the silent FY*BES variant, commonly reaching fixation across stretches of the continent. The maps presented not only represent the first spatially and genetically comprehensive description of variation at this locus, but also constitute an advance towards understanding the transmission patterns of the neglected P. vivax malaria parasite.
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机译:血型变异是人群的特征,可以显示明显的地理格局。 Duffy血型变异的全球流行兴趣是多学科的,但由于Duffy阴性表型通常对间日疟原虫感染具有抗药性,因此对疟疾学家尤为重要。在这里,我们整理了一个广泛的调查地理数据库,形成了多地点贝叶斯地统计模型的证据基础,以生成常见Duffy等位基因的全局频率图,以完善常见Duffy变体的全局制图。我们显示,全球最普遍的等位基因是FY * A,而在整个撒哈拉以南非洲,主要的等位基因是沉默的FY * B ES sup>变异体,通常在整个非洲大陆上都达到固定。呈现的图谱不仅代表了该场所变异的第一个空间和遗传综合描述,而且还构成了了解被忽略的间日疟原虫疟疾寄生虫传播方式的进步。
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