Thousands of electronic cigarette refill fluids are commercially available. The concentrations of nicotine and the solvents, but not the flavor chemicals, are often disclosed on product labels. The purpose of this study was to identify and quantify flavor chemicals in 39 commercial refill fluids that were previously evaluated for toxicity. Twelve flavor chemicals were identified with concentrations ≥1 mg/ml: cinnamaldehyde, menthol, benzyl alcohol, vanillin, eugenol, p-anisaldehyde, ethyl cinnamate, maltol, ethyl maltol, triacetin, benzaldehyde, and menthone. Transfer of these flavor chemicals into aerosols made at 3V and 5V was efficient (mean transfer = 98%). We produced lab-made refill fluids containing authentic standards of each flavor chemical and analyzed the toxicity of their aerosols produced at 3V and 5V using a tank Box Mod device. Over 50% of the refill fluids in our sample contained high concentrations of flavor chemicals that transferred efficiently to aerosols at concentrations that produce cytotoxicity. When tested with two types of human lung cells, the aerosols made at 5V were generally more toxic than those made at 3V. These data will be valuable for consumers, physicians, public health officials, and regulatory agencies when discussing potential health concerns relating to flavor chemicals in electronic cigarette products.
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机译：数以千计的电子香烟补充液可商购获得。产品标签上经常披露尼古丁和溶剂（而不是风味化学品）的浓度。这项研究的目的是鉴定和定量以前评估过毒性的39种商业补充液中的风味化学物质。鉴定出浓度≥1μg/ ml的十二种香料化学品：肉桂醛，薄荷醇，苯甲醇，香兰素，丁子香酚，对茴香醛，肉桂酸乙酯，麦芽酚，乙基麦芽酚，三醋精，苯甲醛和薄荷酮。将这些风味化学物质转移到以3V和5V制成的气溶胶中是有效的（平均转移率= 98％）。我们生产了实验室制造的补充液，其中含有每种调味品的真实标准品，并使用Box Mod Mod罐分析了在3V和5V下产生的气雾剂的毒性。在我们的样品中，超过50％的补充液中含有高浓度的风味化学物质，这些化学物质以产生细胞毒性的浓度有效地转移到气溶胶中。用两种类型的人肺细胞进行测试时，通常在5V下产生的气溶胶比在3V下产生的气溶胶毒性更大。当讨论与电子烟产品中的香精化学有关的潜在健康问题时，这些数据对于消费者，医生，公共卫生官员和监管机构将是有价值的。
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